Melatonin ineffective for insomnia but effective for other sleep problemsAs a treatment for chronic insomnia, melatonin supplements disappoint. Internal secretion of melatonin, the hormone of darkness, begins to rise some two hours before you fall asleep. Adding to it with a melatonin supplement is often redundant.

But there’s increasing evidence that melatonin supplementation is effective for some sleep problems and may also help to treat and/or avert serious health conditions. Here’s a summary of the benefits.

Shifting the Timing of Sleep

Supplementary melatonin can be used as a chronobiotic—an agent that brings about a phase adjustment of the body clock. It can shift the timing (but not the duration) of your sleep. So it’s an effective therapeutic in at least two situations:

  1. As a jet lag remedy: Eastward travel across several time zones is difficult. Your body clock has to shift forward several hours until sleep syncs up with darkness in the new time zone. A melatonin tablet taken before a late afternoon or early evening departure (together with reduced light exposure) may help to initiate this phase advance and serve as a jet lag remedy. From day 1 you’ll fall asleep earlier and wake up earlier, starting out on the right foot.
  2. As a maintenance therapy for night owls: If you come alive in the evening and can’t get to sleep till 2 or 3 a.m., chances are your body clock runs late. Instead of completing a daily period every 24 hours, a daily period for you may be closer to 25 hours and even longer. The medical diagnosis for this problem is delayed sleep phase disorder, or DSPD. People with DSPD have a tough time getting up for early morning classes and work. The solution is twofold: bright light exposure in the morning and a daily melatonin supplement taken around dinnertime. (For details see this blog post on DSPD.) Recently, melatonin was found to be quite effective in helping adolescent night owls fall asleep earlier so they could rise ‘n’ shine in time for early morning classes.

Correcting a Melatonin Deficiency

Melatonin is secreted by the pineal gland. It helps to create the relatively strong biological rhythms that put you to sleep and keep you sleeping through the night. But melatonin rhythms can weaken with age. The following may be involved:

  • degeneration of neurons in the body clock
  • deterioration of neurons connected to the pineal gland
  • calcification of the pineal gland

All of these factors are associated with melatonin deficiency and will make it harder to fall and stay asleep.

How can you know if you’re deficient in melatonin? An easy way is to test for the main melatonin metabolite in a urine sample collected during the first void of the morning. Testing for melatonin in the saliva and the blood is more involved. Home test kits are available, but you’re more certain to get accurate results from tests ordered by a doctor.

Older adults deficient in melatonin may find their sleep improves when they take a daily melatonin supplement. Timed-release melatonin is now available over the counter in the United States. Particularly if your problem is sleep maintenance insomnia (you wake up several times at night), a timed-release supplement will probably be more effective than immediate-release tablets, which exit the system fairly quickly.

Other Benefits of Melatonin Supplementation

Melatonin may have other health-protective effects. It’s been found to act as a powerful antioxidant in laboratory tests. In a review paper published last year, Lionel H. Opie and Sandrine Lecour cite evidence that melatonin may be effective in helping:

  • lower hypertension
  • reduce damage to body tissue after a heart attack
  • protect against, and reduce cell death following, strokes
  • prevent the adverse health effects of obesity
  • treat type 2 diabetes

Weaker evidence suggests that melatonin may help combat some cancers, including prostate and breast cancer.

If you’re a garden-variety insomniac like me, you may not think much of melatonin. But don’t you have to love it a little bit for all the things it can do?

If you’ve tried melatonin for sleep or some other reason, how did it work?

Posted by Lois Maharg, The Savvy Insomniac

Lois Maharg has worked with language for many years. She taught ESL, coauthored two textbooks, and then became a reporter, writing about health, education, government, Latino affairs, and food. Her lifelong struggle with insomnia and interest in investigative reporting motivated her to write a book, The Savvy Insomniac: A Personal Journey through Science to Better Sleep. She now freelances as an editor and copy writer at On the Mark Editing.


  1. Melatonin In any form has never helped me; not the liquid sublingual kind, tablets in various strengths, etc. What has helped me the most is a Fisher Wallace Stimulator, an electronic device that stimulates your own production of melatonin and serotonin. It’s not cheap at $700 but it comes with a 30 day guarantee/trial period and I’ve repeatedly been desperate enough to pay any amount. I’d recommend it to anyone looking for a solution.



    1. Hi Nancy,

      Thanks for your comments about melatonin and the device that has helped you sleep. Several similar devices are on the market now. I have no personal experience with any of them. But here’s a blog post I wrote on the topic a couple years ago: It may be helpful to others wondering about trying this type of treatment themselves.



  2. […] Melatonin supplements are also of high interest to readers, especially in timed-release formulations. But melatonin is not a sleeping pill. Its usefulness lies in its ability to shift the timing of sleep. Melatonin is sometimes recommended to night owls whose daytime schedules make it necessary to go to sleep earlier than they would following their natural inclinations. It also helps lessen jet lag. […]



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